FDA Approves Inhalable Diabetes Medication.
News that the FDA approved Friday an inhalable diabetes medication, Afrezza, was covered by majorUSnewspapers, news agencies and by at least one television network. Several media outlets highlighted the challenges faced by the product’s manufacturer, MannKind Corp., and how the medication was approved in the shadow of failures of other companies to develop such a product
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USAendocrinologists concerned insurers’ decision to stop covering certain diabetic medications may impact glycemic control.
MedPage Today reported that endocrinologists are concerned that recent decisions by insurers to stop covering certain diabetic medications could have an impact on glycemic control. For instance, Express Scripts, the largest pharmacy benefits manager in the country, no longer pays for two top-selling Novo Nordisk products NovoLog (insulin aspart) and Victoza (liraglutide) and has also cut out other popular therapies such as the Nesina (alogliptin) and Tradjenta (linagliptin).
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New Hydrogel Product May Help Overweight, Obese Patients Lose Weight.
Research presented at the Endocrine Society/ICE meeting indicated overweight and obese patients who took 2 doses a day of a biocompatible hydrogel that is not systemically absorbed were able to significantly decrease their body weight. The new product, Gelesis100, contains thousands of tiny hydrogel particles, administered in capsules that dissolve and expand in the stomach and mix with ingested food, creating a larger volume and inducing satiety, but then later eliminated.
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Experimental chemoradionuclide may increase survival in neuroendocrine tumors.
A research published in EJNMMI and presented at the Society of Nuclear Medicine and Molecular Imaging 2014 Meeting suggests that treatment with an experimental chemoradionuclide in combination with chemotherapy can increase survival in patients with inoperable neuroendocrine tumors that express high levels of somatostatin receptors. This therapy, known as peptide receptor chemoradionuclide therapy (PRCRT), combines 177Lu-DOTA-octreotate chemoradionuclide with fluorouracil chemotherapy
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New Growth-Hormone Once Weekly May Be Beneficial in AGHD.
A new GH derivative injected once a week for treatment of adult growth-hormone deficiency shows a comparable dose response and tolerability profile to daily injectable somatropin (Norditropin), according to results of the first trial in adult patients. The data indicated that IGF-1 was elevated at all tested doses of the new once-weekly NNC0195-0092 (Novo Nordisk)
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Insulin Sooner Rather Than Later May Do More Harm Than Good
Research published in JAMA suggests prescribing insulin sooner rather than later in type 2 DM could do more harm than good. Investigators compared health of veterans who were given insulin or an oral medication after their blood sugar levels could no longer be controlled just by metformin. Patients who received insulin experienced a 30 percent greater risk for the combined outcome of heart attacks, strokes or death.
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Clinical Guidelines For Management Of Patients With Rare Adrenal Tumors.
The Endocrine Society, the American Association for Clinical Chemistry, and the European Society of Endocrinology have issued the first-ever clinical practice guidelines for the management of patients with rare adrenal tumors such as pheochromocytoma and paraganglioma. This guidance was published online June 3 in the JCEM by an international task force.
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Analysts Expect New Obesity Medicine To Get FDA Nod.
The FDA is expected to decide by Wednesday whether to approve Orexigen Therapeutics obesity medicine Contrave (bupropion and naltrexone), and analysts expect approval of the medicine. The piece also analyzed the fate of two other obesity medicines, Vivus’ Qsymia (phentermine and topiramate extended-release) and Arena’s Belviq (lorcaserin HCl), noting they had lackluster sales. Still, analysts believe that the cardiovascular outcomes trial Orexigen was required to run may actually give it the advantage over Vivus and Arena because it’ll have more data on the safety of its drug sooner.
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Cinacalcet May Improve CV Outcomes In Elderly Hemodialysis Patients
New analysis of data from the EVOLVE trial indicates that in hemodialysis patients with secondary hyperparathyroidism, cinacalcet improves time to death and cardiovascular end points, but only in those 65 years and older. Dr. Parfrey presented the findings at the European Renal Association-European Dialysis and Transplant Association Congress.
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Experimental Sanofi Insulin May Control Diabetes Better Than Insulin Glargine.
A research presented at ADA meeting indicates experimental insulin Toujeo controlled diabetes better than Lantus. Researchers found, in an analysis of three trials of Toujeo, also known as U300, the drug to have 31% fewer hypoglycemia compared with Lantus.
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Researchers Reverse Type 1 Diabetes In Mice.
Using an antibody called UT18 to stimulate a molecule called TLR4 prevented T-cells from attacking beta cells may reversed type 1 diabetes in mice. The approach reversed type 1 diabetes in a large percentage of non-obese mice that had just developed the disease. The findings were presented at the ADA meeting.
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Researchers Convert Human Gut Cells Into Insulin Producers
Bloomberg News reports researchers have converted human gut cells into insulin producers by turning off a single. The investigators, using a miniature model of the human intestine, only a few millimeters in size and made from stem cells, deactivated a gene in the cells tied to metabolic regulation called FOXO1. After being disabled, the cells began producing insulin. The findings were published in Nature Communications.
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