Researchers Identify New Drug Target For Diabetes.
Researchers at Johns Hopkins compared diabetic and healthy rats and observed a fundamental imbalance in the enzyme levels within cell mitochondria with higher levels of O-GlcNAc transferase (which adds O-GlcNAc to proteins) and lower levels of O-GlcNAcase, which removes the molecule. The team concluded that creation of a drug that could balance these enzymes would lead to a new approach to preventing or treating diabetes. The study was reported in Proceedings of the National Academy of Sciences
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FDA Warns SGLT2 inhibitors May Cause Ketoacidosis.
FDA announced that the new class of diabetes medications SGLT2 inhibitors, including Farxiga (dapagliflozin), Invokana (canagliflozin), and Jardiance (embagliflozin), may cause ketoacidosis. The FDA received 20 adverse event reports detailing ketoacidosis from March 2013 to June 6, 2014, and has continued to receive reports since.
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Histrelin Implant May Be Viable Option For Central Precocious Puberty.
A study in JCEM involving 33 girls and 3 boys, found an implant providing controlled delivery of histrelin at 65 µg/day over 12 months, offered sustained suppression of the hypothalamic-pituitary-gonadal axis and improved height.
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No Evidence That GH Therapy Increases Likelihood Of Neoplasms In Kids
A study published in JCEM reported no evidence GH therapy increases risk of neoplasms in children with no additional risk factors.
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Subclinical Hyperthyroidism Linked To Higher Risk For Certain Fractures.
Research in JAMA looking at 13 past studies involving more than 70,000 patients suggests even people with only mild hyperthyroidism have an elevated risk for fractures.
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From the American Urological Association 2015 annual meeting:
- Testosterone May Not Cause Prostate Cancer Or Increases In PSA.
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- Testosterone Treatment May Not Increase Thrombotic Events In Elderly Men.
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- Testosterone May Be Beneficial In Hypogonadal Men With Diabetes.
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Thyroid-Cancer Survivors May have Increased Risk For Breast Cancer
Data from the SEER 1973–2011 presented at the annual meeting of endocrine surgeons suggests thyroid-cancer survivors are at increased risk for developing breast cancer compared with the general population. Earlier at the Endocrine Society meeting, same authors presented reverse findings from same database: breast cancer patients are at increased risk for thyroid cancer.
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NIH Awards NY Universities $10.5M Grant For Diabetes Research.
The NIH awarded a five-year, $10.5 million grant to Albert Einstein College of Medicine of Yeshiva University and Icahn School of Medicine at Mount Sinai for diabetes research
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