FDA limits use of testosterone drugs, warns of possible heart risk
The FDA announced it will require manufacturers of prescription testosterone therapy to include a warning about health risks on product labels, and the agency advised men using such products to contact a doctor if they develop symptoms of heart attack or stroke. While drug companies marketed testosterone directly to men experiencing age-related changes such as energy loss and reduced sex drive, the FDA says there is no evidence that taking testosterone is safe or effective for men experiencing those natural changes.
Thyroid Nodules May Not Need To Be Monitored As Closely As Recommended
A study published in JAMA indicates thyroid nodules may not need to be monitored as closely as current guidelines recommend. Investigators tracked nearly 1,000 patients with presumably benign thyroid nodules. After five years of monitoring with yearly ultrasound scans, most nodules showed no substantial change; just five nodules – 0.3 percent – were eventually diagnosed as cancer . The editorial agreed that current guidance can be relaxed.
Hormone Therapy In Postmenopausal Women May Not Impact Mortality
Research presented at The Endocrine Society annual meeting indicated hormone therapy in postmenopausal women was not linked to significant effect on all-cause mortality, cardiovascular death, or breast cancer death. In a review of 43 randomized trials, there was no association between all-cause mortality and the therapy, for either estrogen only or combined with progesterone (risk ratio 0.99, 95% CI 0.94-1.05). The study also indicated that HRT was not associated with mortality due to MI (RR 1.04, 95% CI 0.87-1.23), breast cancer (RR 0.93, 95% CI 0.26-3.32), or stroke (RR 1.49, 95% CI 0.95-2.31).
Abaloparatide May Reduce Fractures In High-Risk Postmenopausal Women
Research presented at Endocrine Society’s annual meeting indicated the investigational Parathyroid-hormone-related protein (PTHrP) analog abaloparatide (Radius Health) was associated with an 86% reduction in vertebral fracture incidence compared with placebo.
Breast Cancer Survivors May Have Higher Risk Of Developing Thyroid Cancer.
Research presented at the Endocrine Society annual meeting suggests breast cancer survivors may have higher risk of thyroid cancer compared with the general population. Researchers found the association stronger for younger breast cancer survivors.
Vagal Blocking Device For Treatment Of Obesity Safer Than Bariatric Surgery.
Medscape reports that in January, the FDA approved the VBLOC vagal blocking therapy, a rechargeable neuroregulator device implanted into the lateral chest wall with flexible leads placed laparoscopically around the vagus nerve, intermittently blocking signals and thereby reducing hunger and increasing feelings of satiety. The device is intended to treat obese adults with BMI 40 to 45 kg/m² or over 35 kg/m² with comorbid conditions who failed at least one supervised weight-management program within the past five years.
Statin Therapy Appears To Increase Men’s Risk For Type 2 Diabetes.
A study in Diabetologia suggests men prescribed statins had a 46% greater chance of developing diabetes after six years. In addition, statins seemed to make people more resistant to the effects of insulin and to secrete less insulin. Researchers arrived at these conclusions after investigating the effects of statin treatment on blood glucose control and the risk for type 2 diabetes in 8749 nondiabetic men age 45 to 73 years in a 6-year follow-up of the population-based Metabolic Syndrome in Men (METSIM) trial.